SCHEMBL2446597

SCHEMBL2446597

Nc1ccc(Oc2ccc(C3(c4ccc(Oc5ccc(N)cc5)c(C(F)(F)F)c4)c4ccccc4-c4ccccc43)cc2C(F)(F)F)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
MAPT P10636 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
KDM4E B2RXH2 1/20 0.51
LMNA P02545 1/20 0.51
OPRK1 P41145 1/20 0.51
NCOA1 Q15788 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
PDK2 Q15119 7/20 0.39
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
MAOA P21397 2/20 0.35
AR P10275 2/20 0.34
RAB9A P51151 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
GAA P10253 2/20 0.33
POLB P06746 2/20 0.33
NPC1 O15118 1/20 0.33
NLRP3 Q96P20 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2444878 0.93 KDM4E (0.51) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2446258 0.90 KDM4E (0.50) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2440298 0.88 MAPT (0.51) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL28439403 0.86 SMN1; SMN2 (0.43) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2445169 0.85 MEN1 (0.50) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2439551 0.84 KDM4E (0.44) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2441656 0.84 KDM4E (0.44) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL29418332 0.84 KDM4E (0.44) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2450314 0.84 KDM4E (0.44) MEN1KMT2AMAPTSMN1; SMN2KDM4E
SCHEMBL2446243 0.82 KDM4E (0.44) MEN1KMT2AMAPTSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2128193-B1 POROUS POLYIMIDE IBIDEN CO LTD (JP) 2013-06-19 EP disclosed
US-8022110-B2 Porous polyimide IBIDEN CO., LTD. (JP) 2011-09-20 US disclosed
US-20100048745-A1 POROUS POLYIMIDE IBIDEN CO., LTD (JP) 2010-02-25 US disclosed
EP-2128193-A1 POROUS POLYIMIDE Ibiden Co., Ltd. (JP) 2009-12-02 EP disclosed