Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.42 |
| ▸ | ATF1 | P18846 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 5/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.40 |
| ▸ | RELA | Q04206 | 5/20 | 0.40 |
| ▸ | FOS | P01100 | 4/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30064926 | 0.83 | MAPT (0.42) | KDM4EALDH1A1ALOX15NFKB1IRAK4 | |
| SCHEMBL22208073 | 0.83 | MAPT (0.42) | KDM4EALDH1A1ALOX15NFKB1IRAK4 | |
| SCHEMBL29374417 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1ALOX15NFKB1IRAK4 | |
| SCHEMBL22497793 | 0.82 | ALDH1A1 (0.46) | KDM4EALDH1A1ALOX15NFKB1IRAK4 | |
| SCHEMBL20330716 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1ALOX15NFKB1ATF1 | |
| SCHEMBL30341786 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1ALOX15TP53MAPT | |
| SCHEMBL502657 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1ALOX15TP53MAPT | |
| SCHEMBL1521390 | 0.81 | ALDH1A1 (0.43) | KDM4EALDH1A1ALOX15IRAK4TP53 | |
| SCHEMBL16873158 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1ALOX15NFKB1ATF1 | |
| SCHEMBL20892112 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1ALOX15TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575153-B2 | Pyridine-3-carboxyamide derivative | KOWA COMPANY, LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| EP-2380877-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | Kowa Company, Ltd. (JP) | 2011-10-26 | — | — | EP | disclosed |
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | KOWA COMPANY, LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237590-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | JAK3, JAK1, UACA | KDM4E 1516/4885ALDH1A1 2676/4885ALOX15 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.