SCHEMBL24469640

SCHEMBL24469640

CC(C)CC1CNCc2cnccc21

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 1/20 0.34
CDK2 P24941 1/20 0.34
CCNA1 P78396 1/20 0.34
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33
DRD2 P14416 1/20 0.33
DRD1 P21728 1/20 0.33
PRCP P42785 1/20 0.31
PIM1 P11309 1/20 0.30
PIM2 Q9P1W9 1/20 0.30
CYP2D6 P10635 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24469485 0.78 MEN1 (0.47) CHRNB2CHRNA4DRD2PRCPCYP2D6
SCHEMBL27010607 0.77 CHRNB2 (0.36) CHRNB2CHRNA4DRD2DRD1
SCHEMBL26620745 0.74 HTR2C (0.42) CHRNB2CHRNA4DRD2DRD1SLC6A2
SCHEMBL21267253 0.71 PIM1 (0.37) CCNA2CDK2CCNA1PRCPPIM1
SCHEMBL19289415 0.69
SCHEMBL24316217 0.68 CHRNB2 (0.36) CHRNB2CHRNA4DRD2DRD1
SCHEMBL20646064 0.67 CHRNB4 (0.38)
SCHEMBL26620755 0.65 CHRNB2 (0.39) CHRNB2CHRNA4DRD2DRD1CYP2D6
SCHEMBL3411216 0.64 DRD2 (0.44) CHRNB2CHRNA4DRD2DRD1
SCHEMBL22020578 0.63 CHRNB2 (0.40) CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023116862-A1 HYDROGENATED INDOLE COMPOUND, AND PREPARATION METHOD AND MEDICAL USE THEREFOR 江苏恒瑞医药股份有限公司 2023-06-29 WO disclosed
WO-2023066371-A1 NITROGEN-CONTAINING TETRACYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2023-04-27 WO disclosed
WO-2023011581-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF 江苏恒瑞医药股份有限公司 2023-02-09 WO disclosed
WO-2022111498-A1 PYRIMIDINEDIONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2022-06-02 WO disclosed