Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29588108 | 1.00 | ERN1 (0.52) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL10039710 | 0.93 | ERN1 (0.52) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL909951 | 0.81 | LMNA (0.42) | ERN1LMNAHPGDNPC1MAPT | |
| SCHEMBL16649377 | 0.79 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL9376591 | 0.79 | ERN1 (0.63) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL30310943 | 0.79 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL17822053 | 0.76 | ERN1 (0.49) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL15428163 | 0.75 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL24823392 | 0.75 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL17397860 | 0.75 | ERN1 (0.63) | ERN1DYRK1ADYRK2DYRK1BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4249474-A1 | TRIAZINE DIONE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN MEDICINE | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-09-27 | — | — | EP | disclosed |
| CN-116507621-A | Pyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-116323598-A | Triazine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| WO-2022111498-A1 | PYRIMIDINEDIONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2022-06-02 | — | — | WO | disclosed |