Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29588108 | 0.93 | ERN1 (0.52) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL24469645 | 0.93 | ERN1 (0.52) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL909951 | 0.81 | LMNA (0.42) | ERN1NPC1MAPTRAB9A | |
| SCHEMBL17822053 | 0.80 | ERN1 (0.49) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL30311078 | 0.79 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL15428163 | 0.79 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL17397860 | 0.79 | ERN1 (0.63) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL24823392 | 0.79 | ERN1 (0.48) | ERN1DYRK1ADYRK2DYRK1BCHRM2 | |
| SCHEMBL18106768 | 0.77 | MEN1 (0.42) | ERN1KCNH2NPC1MAPTRAB9A | |
| SCHEMBL16785317 | 0.77 | MEN1 (0.42) | ERN1KCNH2NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113185452-A | Urea derivatives or pharmaceutically acceptable salts thereof | 杏林制药株式会社 | 2021-07-30 | — | — | CN | disclosed |
| CN-107849049-B | Urea derivatives or pharmaceutically acceptable salts thereof | 杏林制药株式会社 | 2021-03-16 | — | — | CN | disclosed |
| EP-3331884-B1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KYORIN SEIYAKU KK (JP) | 2020-06-17 | — | — | EP | disclosed |
| US-20180207153-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2018-07-26 | — | — | US | disclosed |
| EP-3331884-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2018-06-13 | — | — | EP | disclosed |
| WO-2016189876-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2016-12-01 | — | — | WO | disclosed |
| WO-2012019430-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207153-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | FPR1, FPR2, SAAL1 | ERN1 857/4885DYRK1A 4293/4885DYRK2 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.