Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447152 | 0.80 | MAPT (0.43) | MAPTTAS1R3TAS1R1TP53LMNA | |
| SCHEMBL25412023 | 0.73 | MAPT (0.60) | MAPTTP53LMNAHTR2CPOLB | |
| SCHEMBL17321037 | 0.73 | MAPT (0.54) | MAPTTP53LMNAPOLBTDP1 | |
| SCHEMBL31435418 | 0.73 | MAPT (0.54) | MAPTTP53LMNAPOLBTDP1 | |
| SCHEMBL2441879 | 0.72 | MAPT (0.46) | MAPTTP53HTR2CPOLBTDP1 | |
| SCHEMBL28921266 | 0.70 | MAPT (0.42) | MAPTTHRBTDP1 | |
| SCHEMBL30443481 | 0.69 | PIM1 (0.42) | MAPTLMNATHRB | |
| SCHEMBL2441214 | 0.69 | HIF1A (0.41) | — | |
| Cyclopropane SCHEMBL2441589 | 0.66 | SCD5 (0.40) | MAPTLMNA | |
| Cyclopropane SCHEMBL2438822 | 0.66 | SCD (0.39) | MAPTTP53HTR2APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893589-B1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-09-14 | — | — | EP | claimed |