Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29652381 | 0.84 | MAPT (0.50) | MAPTCHEK1MAP4K4ABL1NTRK1 | |
| SCHEMBL1759452 | 0.84 | MAPT (0.50) | MAPTCHEK1MAP4K4ABL1NTRK1 | |
| SCHEMBL2447151 | 0.80 | MAPT (0.47) | MAPTTAS1R3TAS1R1TP53LMNA | |
| SCHEMBL13486441 | 0.73 | IKBKE (0.45) | MAP4K4NTRK1PRKACAKDRGSK3B | |
| SCHEMBL8233882 | 0.71 | F9 (0.47) | MAPTCHEK1MAP4K4ABL1NTRK1 | |
| SCHEMBL8945166 | 0.70 | MAPT (0.39) | MAPTTAS1R3TAS1R1TP53LMNA | |
| SCHEMBL7763399 | 0.70 | TBK1 (0.44) | MAPTTP53LMNAHTTRAB9A | |
| SCHEMBL12044601 | 0.70 | RAB9A (0.41) | MAPTTP53LMNATSHRHTT | |
| SCHEMBL17442796 | 0.69 | MAPT (0.50) | MAPTKDRFLT3AURKBTP53 | |
| SCHEMBL17442795 | 0.69 | MAPT (0.47) | MAPTCHEK1MAP4K4ABL1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893589-B1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-09-14 | — | — | EP | claimed |