Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trospium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 11/20 | 1.00 |
| ▸ | CHRM2 known ✓ | P08172 | 10/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trospium SCHEMBL119810 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL724191 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL31112961 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL22609933 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL29389006 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL111738 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL13836646 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL29629492 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL25785 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL1707994 | 0.93 | CHRM3 (0.89) | CHRM3CHRM2CHRM1KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1880718-B1 | Pharmaceutical preparation for oral administration with controlled drug release in the small intestine colon and process of prepartion thereof | PFLEGER R CHEM FAB (DE) | 2011-09-21 | — | — | EP | claimed |
| EP-4323367-A1 | 3H,4H-THIENO[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2024-02-21 | — | — | EP | disclosed |
| EP-4323364-A1 | IMIDAZO[4,5-D]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2024-02-21 | — | — | EP | disclosed |
| EP-4323355-A1 | URACIL DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2024-02-21 | — | — | EP | disclosed |
| EP-4228756-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2023-08-23 | — | — | EP | disclosed |
| EP-4228755-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2023-08-23 | — | — | EP | disclosed |
| EP-4171563-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2023-05-03 | — | — | EP | disclosed |
| EP-4171571-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2023-05-03 | — | — | EP | disclosed |
| WO-2022219012-A1 | 3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-10-20 | — | — | WO | disclosed |
| WO-2022219013-A1 | URACIL DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-10-20 | — | — | WO | disclosed |
| WO-2022219015-A1 | IMIDAZO[4,5-d]PYRIDAZINONYL DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-10-20 | — | — | WO | disclosed |
| WO-2022219014-A1 | 3H,4H-THIENO[2,3-d]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-10-20 | — | — | WO | disclosed |
| EP-4045144-A1 | THIENOPYRIMIDONES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-08-24 | — | — | EP | disclosed |
| EP-4045509-A1 | THIENOPYRIMIDONES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2022-08-24 | — | — | EP | disclosed |
| EP-4045053-A1 | NOVEL TETRAZOLES | Boehringer Ingelheim International GmbH (DE) | 2022-08-24 | — | — | EP | disclosed |
| WO-2022079091-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022079092-A1 | TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-04-21 | — | — | WO | disclosed |