Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trospium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 11/20 | 1.00 |
| ▸ | CHRM2 known ✓ | P08172 | 10/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trospium SCHEMBL2447242 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL119810 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL31112961 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL22609933 | 0.99 | CHRM3 (0.97) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL29389006 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL111738 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL13836646 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL29629492 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL25785 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL1707994 | 0.93 | CHRM3 (0.89) | CHRM3CHRM2CHRM1KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119345298-A | Traditional Chinese medicine health tea and preparation method and application thereof | 日照市东港区灵丹草养生茶厂(个体工商户) | 2025-01-24 | — | — | CN | claimed |
| CN-118262786-B | Crop area test organism-environment multidimensional information data model | 华中农业大学 | 2024-12-03 | — | — | CN | claimed |
| CN-115104472-B | Efficient forest grass restoration method for purple sand shale erosion area | 广东省林业科学研究院 | 2024-07-26 | — | — | CN | claimed |
| CN-118262786-A | Crop area test organism-environment multidimensional information data model | 华中农业大学 | 2024-06-28 | — | — | CN | claimed |
| CN-112715195-B | Method and device for screening island greening salt-reducing plants | 中国科学院亚热带农业生态研究所 | 2023-06-02 | — | — | CN | claimed |
| EP-4035668-A1 | ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS | Chase Pharmaceuticals Corporation (US) | 2022-08-03 | — | — | EP | claimed |
| CN-1086575-C | New stable medicinal compositions for generating propellant-free aerosols | BOEHRINGER INGELHEIM KG (DE) | 2002-06-26 | — | — | CN | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| CN-122094976-A | Multichain chimeric polypeptides and uses thereof | — | 2026-05-26 | — | — | CN | disclosed |
| EP-4705289-A1 | PRODRUGS OF XANOMELINE, PRODRUGS OF TROSPIUM AND METHODS OF USE THEREOF | Terran Biosciences Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| US-20250351819-A1 | NANOSTRUCTURED METALLIC SUBSTRATES AND SURFACES TO DEACTIVATE MICROBES | COLORADO SCHOOL OF MINES (US) | 2025-11-20 | — | — | US | disclosed |
| US-12376585-B2 | Nanostructured metallic substrates and surfaces to deactivate microbes | COLORADO SCHOOL OF MINES (US) | 2025-08-05 | — | — | US | disclosed |
| CN-119948033-A | Method for extracting phragmalin derivatives from cercis-male seeds and preparing limonin analogues with pharmaceutical activity | 迪科特制药公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-119345298-A | Traditional Chinese medicine health tea and preparation method and application thereof | 日照市东港区灵丹草养生茶厂(个体工商户) | 2025-01-24 | — | — | CN | disclosed |
| CN-1085526-C | Air pressed package using polyoxyethylene glyceryl oleate | ASTA PHARMACEUTICAL CO LTD (DE) | 2002-05-29 | — | — | CN | disclosed |
| CN-1069191-C | Compressed air packaging using polyoxyethylene glyceryl oleate | ASTA MEDICA AG (DE) | 2001-08-08 | — | — | CN | disclosed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | disclosed |
| CN-1259343-A | Air pressed package using polyoxyethylene glyceryl oleate | ASTA PHARMACEUTICAL CO LTD (DE) | 2000-07-12 | — | — | CN | disclosed |
| CN-1259342-A | Air pressed package using polyoxyethylene glyceryl oleate | ASTA PHARMACEUTICAL CO LTD (DE) | 2000-07-12 | — | — | CN | disclosed |
| CN-1080846-A | Compressed air packaging using polyoxyethylene glyceryl oleate | ASTA MEDICA AG (DE) | 1994-01-19 | — | — | CN | disclosed |