Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trospium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 11/20 | 0.97 |
| ▸ | CHRM2 known ✓ | P08172 | 10/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.97 |
| ▸ | HRH1 | P35367 | 3/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.95 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trospium SCHEMBL724191 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL119810 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL2447242 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL13836646 | 0.97 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL22609933 | 0.97 | CHRM3 (0.97) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL111738 | 0.97 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL25785 | 0.97 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL29389006 | 0.97 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL29629492 | 0.97 | CHRM3 (1.00) | CHRM3CHRM2CHRM1KCNH2HRH1 | |
| Trospium SCHEMBL1707994 | 0.92 | CHRM3 (0.89) | CHRM3CHRM2CHRM1KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705289-A1 | PRODRUGS OF XANOMELINE, PRODRUGS OF TROSPIUM AND METHODS OF USE THEREOF | Terran Biosciences Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226691-A1 | PRODRUGS OF XANOMELINE, PRODRUGS OF TROSPIUM AND METHODS OF USE THEREOF | TERRAN BIOSCIENCES INC. (US) | 2024-10-31 | — | — | WO | disclosed |