SCHEMBL2447263

SCHEMBL2447263

O=C(Nc1ccccc1F)C1CCCNC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 1/20 0.58
TNKS2 Q9H2K2 1/20 0.58
KMT2A Q03164 3/20 0.53
MEN1 O00255 2/20 0.53
ALDH1A1 P00352 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
POLB P06746 1/20 0.52
GAA P10253 1/20 0.52
LMNA P02545 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
TSHR P16473 1/20 0.51
PARP1 P09874 1/20 0.51
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
HTR6 P50406 2/20 0.49
CDK9 P50750 1/20 0.49
CD274 Q9NZQ7 1/20 0.48
ROCK2 O75116 1/20 0.48
NPC1 O15118 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21669972 0.87 TNKS (0.57) TNKSTNKS2PARP1HTR6CDK9
SCHEMBL43074 0.84 HDAC3 (0.69) KMT2AMEN1ALDH1A1L3MBTL1POLB
SCHEMBL2451469 0.83 TNKS (0.58) TNKSTNKS2ALDH1A1L3MBTL1GAA
SCHEMBL21670367 0.83 TNKS (0.58) TNKSTNKS2PARP1HTR6CDK9
SCHEMBL13588433 0.82 SMN1; SMN2 (0.59) KMT2AMEN1ALDH1A1L3MBTL1POLB
SCHEMBL13703413 0.82 HDAC3 (0.71) KMT2AMEN1ALDH1A1L3MBTL1POLB
SCHEMBL4744831 0.80 SMN1; SMN2 (0.67) KMT2AMEN1ALDH1A1L3MBTL1POLB
SCHEMBL3416580 0.80 SMN1; SMN2 (0.71) TNKSTNKS2KMT2AALDH1A1GAA
SCHEMBL4962811 0.80 TNKS (0.55) TNKSTNKS2ALDH1A1LMNASMN1; SMN2
SCHEMBL4963033 0.80 TNKS (0.55) TNKSTNKS2ALDH1A1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2362775-A1 CHEMICAL COMPOUNDS GlaxoSmithKline LLC (US) 2011-09-07 EP disclosed