Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.44 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21669972 | 0.86 | TNKS (0.57) | TNKSTNKS2ROCK2HTR6CD274 | |
| SCHEMBL2447263 | 0.83 | TNKS (0.58) | TNKSTNKS2ROCK2HTR6CD274 | |
| SCHEMBL22591708 | 0.78 | MEN1 (0.62) | — | |
| SCHEMBL4755192 | 0.77 | SLC6A2 (0.49) | — | |
| SCHEMBL2451469 | 0.77 | TNKS (0.58) | TNKSTNKS2ROCK2HTR6CD274 | |
| Hydrochloric Acid SCHEMBL16670883 | 0.77 | TNKS (0.46) | TNKSTNKS2ROCK2HTR6CD274 | |
| SCHEMBL21669919 | 0.76 | ULK1 (0.56) | ROCK2CDK9CCNT1ULK1F10 | |
| SCHEMBL21669936 | 0.76 | ULK1 (0.56) | ROCK2CDK9CCNT1ULK1F10 | |
| SCHEMBL2449231 | 0.75 | F10 (0.56) | TNKSTNKS2ULK1F10 | |
| SCHEMBL2452221 | 0.75 | F10 (0.56) | TNKSTNKS2ULK1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020028482-A1 | SMALL MOLECULES THAT SENSITIZE HIV-1 INFECTED CELLS TO ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-02-06 | — | — | WO | disclosed |