Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | PRLHR | P49683 | 3/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447305 | 0.85 | CREBBP (0.53) | BRD4CREBBPTRPV1KDM4ENPC1 | |
| SCHEMBL2447276 | 0.83 | JAK3 (0.37) | BRD4CREBBPTRPV1IMPDH2SYK | |
| SCHEMBL2449074 | 0.83 | BRD4 (0.41) | BRD4CREBBPTRPV1IMPDH2KDM4E | |
| SCHEMBL2444491 | 0.82 | TRPV1 (0.37) | BRD4CREBBPTRPV1IMPDH2SYK | |
| SCHEMBL2451710 | 0.82 | BRD4 (0.35) | BRD4CREBBPTRPV1IMPDH2SYK | |
| SCHEMBL2447624 | 0.81 | PDE10A (0.39) | BRD4CREBBPTRPV1IMPDH2SYK | |
| SCHEMBL2449940 | 0.81 | BRD4 (0.36) | BRD4CREBBPTRPV1IMPDH2KDM4E | |
| SCHEMBL2450616 | 0.81 | BRD4 (0.35) | BRD4CREBBPTRPV1IMPDH2KDM4E | |
| SCHEMBL2453297 | 0.80 | BRD4 (0.35) | BRD4CREBBPTRPV1IMPDH2KDM4E | |
| SCHEMBL2446677 | 0.80 | GSK3B (0.36) | BRD4CREBBPTRPV1IMPDH2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | claimed |
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |