Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447276 | 0.89 | JAK3 (0.37) | GSK3BDYRK1ASYKBRD4CREBBP | |
| SCHEMBL2446674 | 0.86 | CREBBP (0.51) | GSK3BDYRK1ASYKBRD4CREBBP | |
| SCHEMBL2451710 | 0.83 | BRD4 (0.35) | GSK3BDYRK1ASYKBRD4CREBBP | |
| SCHEMBL2449074 | 0.82 | BRD4 (0.41) | GSK3BDYRK1ASYKBRD4CREBBP | |
| SCHEMBL2451068 | 0.82 | SYK (0.47) | GSK3BSYKBRD4CREBBPTRPV1 | |
| SCHEMBL2450616 | 0.81 | BRD4 (0.35) | GSK3BDYRK1ASYKBRD4CREBBP | |
| SCHEMBL2452760 | 0.81 | IMPDH2 (0.43) | GSK3BDYRK1ASYKBRD4CREBBP | |
| SCHEMBL2449771 | 0.80 | BRD4 (0.34) | SYKBRD4CREBBPIMPDH2TRPV1 | |
| SCHEMBL2449940 | 0.80 | BRD4 (0.36) | SYKBRD4CREBBPIMPDH2TRPV1 | |
| SCHEMBL2447307 | 0.80 | BRD4 (0.36) | SYKBRD4CREBBPIMPDH2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |