Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447624 | 0.87 | PDE10A (0.39) | BRD4CREBBPIMPDH2TRPV1SYK | |
| SCHEMBL2444491 | 0.87 | TRPV1 (0.37) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2449938 | 0.87 | CREBBP (0.50) | BRD4CREBBPROCK2PDE10APDE5A | |
| SCHEMBL2453297 | 0.85 | BRD4 (0.35) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2449771 | 0.83 | BRD4 (0.34) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2450616 | 0.83 | BRD4 (0.35) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2447307 | 0.81 | BRD4 (0.36) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2449074 | 0.81 | BRD4 (0.41) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2446677 | 0.80 | GSK3B (0.36) | BRD4CREBBPIMPDH2TRPV1ROCK2 | |
| SCHEMBL2451710 | 0.80 | BRD4 (0.35) | BRD4CREBBPIMPDH2TRPV1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | claimed |
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |