Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2379987 | 0.99 | MEN1 (0.43) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2379498 | 0.93 | TRPA1 (0.48) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2380433 | 0.91 | ROCK2 (0.48) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2441509 | 0.87 | MEN1 (0.48) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| Bromide SCHEMBL2379365 | 0.86 | MEN1 (0.47) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2382007 | 0.85 | KMT2A (0.49) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2380592 | 0.85 | ROCK2 (0.53) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2446391 | 0.84 | CYP1A1 (0.50) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2379696 | 0.84 | ROCK1 (0.60) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2444262 | 0.84 | ROCK1 (0.48) | MEN1KMT2AROCK2ROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |