Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL949561 | 0.99 | HTR6 (0.57) | HTR6HTR2AHTR1ADRD2HTR7 | |
| Tert-Butyl Formate SCHEMBL27774718 | 0.89 | HTR6 (0.48) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL2450282 | 0.88 | HTR6 (0.61) | HTR6HTR2AHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL951642 | 0.87 | HTR6 (0.60) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL4688092 | 0.83 | HTR6 (0.56) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL949542 | 0.81 | HTR2A (0.52) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL949399 | 0.79 | HTR6 (0.60) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL950399 | 0.78 | HTR6 (0.51) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3651450 | 0.78 | HTR6 (0.71) | HTR6HTR2AHTR1ADRD2HTR7 | |
| SCHEMBL949296 | 0.77 | HTR6 (0.50) | HTR6HTR2AHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139880-B1 | QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-09-14 | — | — | EP | claimed |