Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1620557 | 0.76 | CA1 (0.39) | ALOX5APFEN1TNFRSF1A | |
| SCHEMBL336062 | 0.74 | NR1H4 (0.36) | ALOX5APFEN1TNFRSF1A | |
| SCHEMBL12098191 | 0.72 | TNFRSF1A (0.40) | TNFRSF1A | |
| SCHEMBL5383978 | 0.72 | CA1 (0.39) | ALOX5APFEN1TNFRSF1A | |
| SCHEMBL8520393 | 0.69 | POLB (0.42) | TNFRSF1A | |
| SCHEMBL3857395 | 0.68 | NFE2L2 (0.45) | TNFRSF1A | |
| SCHEMBL3859840 | 0.68 | ALOX5AP (0.33) | ALOX5APFEN1 | |
| SCHEMBL3835342 | 0.68 | ALOX5AP (0.38) | ALOX5APFEN1 | |
| SCHEMBL11441072 | 0.67 | HPGD (0.41) | ALOX5APFEN1 | |
| SCHEMBL2128910 | 0.66 | CA2 (0.40) | ALOX5APFEN1TNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946289-B2 | Manassatin compounds and methods of making and using the same | DUKE UNIVERSITY (US) | 2015-02-03 | — | — | US | disclosed |
| US-20110230540-A1 | MANASSATIN COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230540-A1 | MANASSATIN COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | HIF1AN, HIF1A, EGLN2 | ALOX5AP 1619/4885FEN1 1953/4885TNFRSF1A 3599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.