Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | MST1R | Q04912 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | FECH | P22830 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791073 | 0.90 | MET (0.70) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2326817 | 0.90 | MET (0.70) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2451612 | 0.85 | MET (0.59) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2452747 | 0.81 | MET (0.69) | METKCNH2MST1R | |
| SCHEMBL2327324 | 0.81 | MET (1.00) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2325911 | 0.81 | MET (1.00) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2322768 | 0.81 | MET (1.00) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2446680 | 0.77 | MET (0.67) | METKCNH2MST1R | |
| SCHEMBL2322587 | 0.75 | MET (0.72) | METKCNH2MST1RAURKAJAK2 | |
| SCHEMBL2326090 | 0.75 | MET (0.75) | METKCNH2MST1RAURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |