Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | MST1R | Q04912 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2452747 | 0.85 | MET (0.69) | METKCNH2MST1R | |
| SCHEMBL2447068 | 0.84 | MET (0.56) | METKCNH2MST1R | |
| SCHEMBL3951023 | 0.83 | MET (0.76) | METKCNH2MST1R | |
| SCHEMBL2451612 | 0.82 | MET (0.59) | METKCNH2MST1R | |
| SCHEMBL2454487 | 0.80 | MET (0.67) | METKCNH2MST1R | |
| SCHEMBL401276 | 0.80 | MET (1.00) | METKCNH2MST1R | |
| SCHEMBL398297 | 0.78 | MET (0.86) | METMST1R | |
| SCHEMBL2447085 | 0.78 | MET (0.82) | METKCNH2MST1R | |
| SCHEMBL2322770 | 0.78 | MET (0.72) | METKCNH2MST1R | |
| SCHEMBL2447025 | 0.78 | MET (0.77) | METKCNH2MST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | claimed |