Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379540 | 0.86 | ROCK2 (0.38) | SMN1; SMN2LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL2420876 | 0.83 | NPSR1 (0.44) | NPSR1HPGDLMNAALDH1A1MAPT | |
| SCHEMBL2383720 | 0.81 | MEN1 (0.46) | NPSR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2379931 | 0.79 | NPSR1 (0.50) | NPSR1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2379381 | 0.78 | SMN1; SMN2 (0.54) | NPSR1HPGDSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2778541 | 0.78 | NPSR1 (0.52) | NPSR1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2419463 | 0.77 | KMT2A (0.46) | NPSR1HPGDLMNAALDH1A1KDM4E | |
| SCHEMBL2781405 | 0.77 | MEN1 (0.46) | NPSR1HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2781508 | 0.76 | ADRA2A (0.53) | NPSR1HPGDALDH1A1MAPTGAA | |
| SCHEMBL2782595 | 0.76 | PLAU (0.49) | NPSR1HPGDALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |