Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | GLA | P06280 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | PDE8A | O60658 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23295690 | 0.87 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL31653998 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL19411063 | 0.76 | KDM4E (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL24477383 | 0.76 | MEN1 (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL24477316 | 0.76 | MEN1 (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL24477314 | 0.76 | MEN1 (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL24477317 | 0.76 | MEN1 (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL24477339 | 0.76 | ALDH1A1 (0.36) | ALDH1A1HPGDSMN1; SMN2RAB9AHTT | |
| SCHEMBL24477379 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL24477393 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022111473-A1 | COMPOUNDS AS MRGPRX2 ANTAGONISTS | BIOARDIS LLC (US) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022111473-A1 | COMPOUNDS AS MRGPRX2 ANTAGONISTS | BIOARDIS LLC (US) | 2022-06-02 | — | — | WO | disclosed |