SCHEMBL24480752

SCHEMBL24480752

CN1CCN(CC2CCN(C3CCN(C)C3)CC2)CC1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NCF1 P14598 1/20 0.39
CACNA2D1 P54289 1/20 0.39
CACNA1B Q00975 1/20 0.39
CACNB1 Q02641 1/20 0.39
CACNA1C Q13936 1/20 0.39
CHRM5 P08912 1/20 0.35
ADRA2C P18825 1/20 0.35
ACHE P22303 1/20 0.35
ALDH1A1 P00352 2/20 0.33
GRIN2B Q13224 1/20 0.32
KCNH2 Q12809 1/20 0.32
POLB P06746 1/20 0.31
KDM1A O60341 1/20 0.31
OPRM1 P35372 1/20 0.31
OPRL1 P41146 1/20 0.31
CHRM3 P20309 1/20 0.30
KDM4E B2RXH2 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24480875 0.91 CACNA2D1 (0.37) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL29317306 0.88 CACNA2D1 (0.34) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL25571687 0.87 NCF1 (0.41) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL24204800 0.87 NCF1 (0.43) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL24480706 0.86 NCF1 (0.44) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL24204675 0.85 NCF1 (0.42) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL25074356 0.85 NCF1 (0.42) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL24480754 0.85 GBA1 (0.36) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL3436997 0.84 NCF1 (0.52) NCF1CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL24204398 0.84 NCF1 (0.41) NCF1CACNA2D1CACNA1BCACNB1CACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131167-A1 COMPOUND FOR INHIBITING AND DEGRADING IRAK4, AND PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF 海思科医药集团股份有限公司 2023-07-13 WO disclosed
WO-2023016518-A1 HETEROCYCLIC DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL USE THEREOF 四川海思科制药有限公司 2023-02-16 WO disclosed
WO-2022111526-A1 BENZENE RING DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL USE THEREOF 四川海思科制药有限公司 2022-06-02 WO disclosed