Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | BCL6 | P41182 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212917 | 0.90 | TP53 (0.80) | TP53LMNAKCNN3POLBBCL6 | |
| SCHEMBL19690859 | 0.87 | KCNN3 (0.71) | TP53LMNAKCNN3POLBHTT | |
| SCHEMBL4210667 | 0.85 | BCL6 (0.64) | TP53LMNAKCNN3POLBBCL6 | |
| SCHEMBL3092078 | 0.81 | HTT (0.63) | TP53LMNAKCNN3POLBHTT | |
| SCHEMBL19700500 | 0.80 | TP53 (0.58) | TP53LMNAKCNN3POLBBCL6 | |
| SCHEMBL19700501 | 0.80 | TP53 (0.58) | TP53LMNAKCNN3POLBBCL6 | |
| SCHEMBL19700496 | 0.80 | TP53 (0.58) | TP53LMNAKCNN3POLBBCL6 | |
| SCHEMBL2447803 | 0.79 | ADORA2A (0.66) | TP53LMNAKCNN3POLBHTT | |
| SCHEMBL4215477 | 0.79 | TP53 (1.00) | TP53LMNAKCNN3POLBHTT | |
| SCHEMBL1936057 | 0.79 | HTT (0.86) | TP53LMNAKCNN3POLBBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355708-A1 | POTASSIUM CHANNEL MODULATORS | CADENT THERAPEUTICS, INC. | 2017-12-14 | — | — | US | disclosed |
| US-20170355708-A1 | POTASSIUM CHANNEL MODULATORS | CADENT THERAPEUTICS, INC. | 2017-12-14 | — | — | US | disclosed |
| US-20170355708-A1 | POTASSIUM CHANNEL MODULATORS | CADENT THERAPEUTICS, INC. | 2017-12-14 | — | — | US | disclosed |
| US-8618099-B2 | Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators | ATAXION, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20110230484-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-22 | — | — | US | disclosed |
| US-20110230484-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-22 | — | — | US | disclosed |
| US-20110230484-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-22 | — | — | US | disclosed |
| CN-102177154-A | Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators | NEUROSEARCH AS | 2011-09-07 | — | — | CN | disclosed |
| WO-2010026087-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230484-A1 | PYRAZOLYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ4, KCNN2 | TP53 3358/4885LMNA 2636/4885KCNN3 5/4885 |
| US-20170355708-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | TP53 4484/4885LMNA 1523/4885KCNN3 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.