Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696689 | 0.89 | KDM4E (0.72) | KDM4EALDH1A1KMT2AMEN1PTPN11 | |
| Hydrochloric Acid SCHEMBL695272 | 0.89 | KDM4E (0.71) | KDM4EALDH1A1KMT2AMEN1PTPN11 | |
| SCHEMBL21926834 | 0.86 | KDM4E (0.71) | KDM4EALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL3164353 | 0.81 | MAPT (0.63) | KDM4EALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL1080500 | 0.81 | MAPK1 (0.57) | KDM4EALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL8480867 | 0.79 | KMT2A (0.60) | KDM4EALDH1A1KMT2AMEN1PTPN11 | |
| SCHEMBL15084346 | 0.79 | KMT2A (0.60) | KDM4EALDH1A1KMT2AMEN1PTPN11 | |
| Hydrochloric Acid SCHEMBL695514 | 0.78 | ALDH1A1 (0.58) | KDM4EALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL2444402 | 0.78 | GAA (0.77) | KDM4EALDH1A1KMT2AMEN1MAPK1 | |
| SCHEMBL3314498 | 0.78 | GAA (0.77) | KDM4EALDH1A1KMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |