Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2379711 | 0.99 | ROCK2 (0.44) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2380592 | 0.90 | ROCK2 (0.53) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2443677 | 0.88 | NPC1 (0.54) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| Bromide SCHEMBL2380827 | 0.87 | NPC1 (0.53) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2380171 | 0.83 | MEN1 (0.52) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2381416 | 0.83 | ROCK2 (0.49) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2379696 | 0.83 | ROCK1 (0.60) | ROCK2ROCK1MEN1KMT2AALDH1A1 | |
| SCHEMBL2380643 | 0.82 | ALDH1A1 (0.60) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2381307 | 0.82 | ROCK2 (0.49) | ROCK2ROCK1MEN1KMT2ANPC1 | |
| SCHEMBL2382007 | 0.82 | KMT2A (0.49) | ROCK2ROCK1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |