Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448845 | 0.88 | TDP1 (0.56) | PKMKMT2AMEN1LMNATSHR | |
| SCHEMBL3949541 | 0.81 | CNR2 (0.66) | PKMKMT2AMEN1LMNATSHR | |
| SCHEMBL4717858 | 0.78 | LMNA (0.70) | PKMKMT2AMEN1LMNATSHR | |
| SCHEMBL2450091 | 0.74 | PKM (0.55) | PKMKMT2AMEN1LMNACNR2 | |
| SCHEMBL4716079 | 0.74 | TDP1 (0.76) | PKMKMT2AMEN1LMNATSHR | |
| SCHEMBL7659574 | 0.74 | PKM (0.61) | PKMKMT2ALMNATSHRCNR2 | |
| SCHEMBL7664954 | 0.74 | PKM (0.61) | PKMKMT2ALMNATSHRCNR2 | |
| SCHEMBL11181821 | 0.74 | PKM (0.54) | PKMKMT2AMEN1LMNATSHR | |
| SCHEMBL4252422 | 0.73 | SMN1; SMN2 (0.77) | PKMKMT2ALMNACNR2CNR1 | |
| SCHEMBL14530332 | 0.73 | PKM (0.60) | PKMKMT2ALMNATSHRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017782-B2 | hypogonadism and male infertility; ovulation induction | N.V. ORGANON (NL) | 2011-09-13 | — | — | US | disclosed |
| CN-101212971-B | 4-phenyl-5-0x0-l,4,5,6,7,8-hexahydr0quin0line derivatives as medicaments for the treatment of infertility | ORGANON NV | 2010-12-08 | — | — | CN | disclosed |
| US-20080262033-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | MERCK SHARP & DOHME B.V. (NL) | 2008-10-23 | — | — | US | disclosed |
| EP-1879581-B1 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | ORGANON NV (NL) | 2008-09-03 | — | — | EP | disclosed |
| CN-101212971-A | 4-phenyl-5-0x0-l,4,5,6,7,8-hexahydr0quin0line derivatives as medicaments for the treatment of infertility | ORGANON NV (NL) | 2008-07-02 | — | — | CN | disclosed |
| EP-1879581-A1 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | N.V. Organon (NL) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117371-A1 | 4-PHENYL-5-0X0-l,4,5,6,7,8-HEXAHYDR0QËIN0LINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | N.V. ORGANON (NL) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262033-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | KCNQ5, SRD5A1, KCNQ1 | PKM 908/4885KMT2A 167/4885MEN1 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.