Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449126 | 0.86 | MET (0.47) | METKCNH2CAMKK2 | |
| SCHEMBL2445891 | 0.86 | MET (0.49) | METKCNH2MST1R | |
| SCHEMBL2449882 | 0.85 | MET (0.60) | METKCNH2 | |
| SCHEMBL2445635 | 0.84 | MET (0.50) | METKCNH2 | |
| SCHEMBL2446402 | 0.84 | MET (0.59) | METKCNH2 | |
| SCHEMBL2447543 | 0.83 | MET (0.44) | METKCNH2MST1R | |
| SCHEMBL2443848 | 0.82 | MET (0.48) | METKCNH2MST1R | |
| SCHEMBL2448783 | 0.82 | MET (0.67) | METKCNH2MST1R | |
| SCHEMBL2449625 | 0.81 | L3MBTL1 (0.47) | METKCNH2MST1R | |
| SCHEMBL2447763 | 0.80 | MET (0.56) | METKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | claimed |
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | disclosed |