Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30336371 | 1.00 | LRRK2 (0.55) | LRRK2DYRK1BPDGFRAFERLTK | |
| Trifluoroacetic Acid SCHEMBL8836917 | 0.86 | LRRK2 (0.42) | LRRK2DYRK1BPDGFRAFERLTK | |
| Ethyne SCHEMBL8836911 | 0.84 | LRRK2 (0.41) | LRRK2DYRK1BPDGFRAFERLTK | |
| SCHEMBL9025284 | 0.84 | PDGFRA (0.55) | LRRK2DYRK1BPDGFRAFERLTK | |
| SCHEMBL7404124 | 0.81 | CA12 (0.55) | LRRK2DYRK1BPDGFRAFERLTK | |
| SCHEMBL8836954 | 0.79 | LRRK2 (0.36) | LRRK2DYRK1BPDGFRAFERLTK | |
| SCHEMBL29483964 | 0.79 | AHR (0.50) | LRRK2DYRK1BPDGFRAFERLTK | |
| SCHEMBL37900 | 0.79 | AHR (0.50) | LRRK2DYRK1BPDGFRAFERLTK | |
| SCHEMBL6619938 | 0.78 | CLK4 (0.62) | LRRK2DYRK1BMAOAMAOBGSK3B | |
| SCHEMBL21619357 | 0.76 | CMA1 (0.51) | LRRK2DYRK1BCA9AHRCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448531-A1 | 3-CYANOQUINOLINES AS INHIBITORS OF EGF-R AND HER2 KINASES | Wyeth Holdings Corporation (US) | 2004-08-25 | — | — | EP | claimed |
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |
| US-20030149056-A1 | 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases | AMERICAN CYANAMID COMPANY | 2003-08-07 | — | — | US | claimed |
| WO-2003050090-A1 | 3-CYANOQUINOLINES AS INHIBITORS OF EGF-R AND HER2 KINASES | WYETH HOLDINGS CORPORATION (US) | 2003-06-19 | — | — | WO | claimed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | claimed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | claimed |
| US-12577227-B2 | WDR5 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2026-03-17 | — | — | US | disclosed |
| US-20220242849-A1 | WDR5 INHIBITORS AND MODULATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-08-04 | — | — | US | disclosed |
| US-10975071-B2 | Inhibitors of KRAS G12C mutant proteins | ARAXES PHARMA LLC (US) | 2021-04-13 | — | — | US | disclosed |
| WO-2021066578-A1 | BICYCLIC COMPOUND AND USE THEREOF | 에스케이바이오팜 주식회사 | 2021-04-08 | — | — | WO | disclosed |
| WO-2020247679-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2020-12-10 | — | — | WO | disclosed |
| US-20200299306-A1 | COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF | UNIVERSITA' DI PISA (IT) | 2020-09-24 | — | — | US | disclosed |
| EP-3679044-A1 | COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF | Università di Pisa (IT) | 2020-07-15 | — | — | EP | disclosed |
| WO-1995021170-A1 | ANTITUMOUR TETRACYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |
| US-5403836-A | Anticoagulants | GENENTECH, INC. (US) | 1995-04-04 | — | — | US | disclosed |
| WO-1995004057-A1 | TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1995-02-09 | — | — | WO | disclosed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5250679-A | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor | GENENTECH, INC. (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993008174-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR | GENENTECH, INC. (US) | 1993-04-29 | — | — | WO | disclosed |
| EP-0150040-A2 | Imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-07-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220242849-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | LRRK2 1406/4885DYRK1B 2149/4885PDGFRA 4440/4885 |
| US-10975071-B2 | Inhibitors of KRAS G12C mutant proteins | KRAS, NRAS, HRAS | LRRK2 39/4885DYRK1B 529/4885PDGFRA 2133/4885 |
| US-12577227-B2 | WDR5 inhibitors and modulators | WDR1, WDR5, WDR3 | LRRK2 1071/4885DYRK1B 2601/4885PDGFRA 3916/4885 |
| US-20030149056-A1 | 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases | EGFR, ERBB2, ERBB3 | LRRK2 439/4885DYRK1B 350/4885PDGFRA 121/4885 |
| US-20200299306-A1 | COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF | MKI67, CCNI, CASP3 | LRRK2 1333/4885DYRK1B 3847/4885PDGFRA 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.