Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.51 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | DRD1 | P21728 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713602 | 1.00 | KDM1A (0.51) | KDM1ASNCAPTGS1PTGS2CYP2D6 | |
| SCHEMBL29713594 | 0.89 | KDM1A (0.47) | KDM1ASNCAPTGS1PTGS2CYP2D6 | |
| SCHEMBL24495137 | 0.89 | KDM1A (0.47) | KDM1ASNCAPTGS1PTGS2CYP2D6 | |
| SCHEMBL24495082 | 0.79 | SLC6A4 (0.54) | CYP2D6LMNACHRM2HTR1AADRA2A | |
| SCHEMBL24495146 | 0.73 | BCHE (0.65) | CYP2D6HTR1ASLC6A4DRD3HTR2B | |
| SCHEMBL29713582 | 0.73 | BCHE (0.65) | CYP2D6HTR1ASLC6A4DRD3HTR2B | |
| SCHEMBL3881700 | 0.73 | CYP3A4 (0.76) | CYP2D6LMNACHRM2HTR1AADRA2A | |
| SCHEMBL5471668 | 0.73 | CYP3A4 (0.76) | CYP2D6LMNACHRM2HTR1AADRA2A | |
| SCHEMBL24406703 | 0.73 | CYP3A4 (0.76) | CYP2D6LMNACHRM2HTR1AADRA2A | |
| SCHEMBL3881699 | 0.73 | CYP3A4 (0.76) | CYP2D6LMNACHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-20220177440-A1 | Fendiline Derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043602-B2 | Fendiline derivatives | CYP11B2, CYP3A7, CYP4F2 | KDM1A 2655/4885SNCA 1460/4885PTGS1 467/4885 |
| US-20220177440-A1 | Fendiline Derivatives | CYP11B2, CYP3A7, CYP4F2 | KDM1A 2655/4885SNCA 1460/4885PTGS1 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.