Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BMP1 | P13497 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496068 | 0.86 | CYP19A1 (0.47) | ALDH1A1PKMCYP19A1HTTLMNA | |
| SCHEMBL29648307 | 0.86 | CYP19A1 (0.47) | ALDH1A1PKMCYP19A1HTTLMNA | |
| SCHEMBL25801783 | 0.84 | TEAD1 (0.46) | ALDH1A1CYP19A1KDM4ECA12CA1 | |
| SCHEMBL29648341 | 0.84 | CYP19A1 (0.47) | CYP19A1KDM4ECA12CA1CA2 | |
| SCHEMBL24496161 | 0.84 | CYP19A1 (0.47) | CYP19A1KDM4ECA12CA1CA2 | |
| SCHEMBL24496152 | 0.82 | CNR2 (0.47) | CYP19A1CA1CA2CA9KMT2A | |
| SCHEMBL29648404 | 0.82 | CYP19A1 (0.45) | ALDH1A1PKMCYP19A1HTTLMNA | |
| SCHEMBL24496309 | 0.82 | CYP19A1 (0.45) | ALDH1A1PKMCYP19A1HTTLMNA | |
| SCHEMBL29648304 | 0.82 | BMP1 (0.51) | BMP1ACP1CA12CA1CA2 | |
| SCHEMBL26669290 | 0.82 | BMP1 (0.51) | BMP1ACP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |