Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496068 | 1.00 | CYP19A1 (0.47) | CYP19A1ALOX15ALDH1A1PTGS2CA1 | |
| SCHEMBL25801783 | 0.89 | TEAD1 (0.46) | CYP19A1ALDH1A1PTGS2CA1CA2 | |
| SCHEMBL29648341 | 0.88 | CYP19A1 (0.47) | CYP19A1PTGS2CA1CA2MAPT | |
| SCHEMBL24496161 | 0.88 | CYP19A1 (0.47) | CYP19A1PTGS2CA1CA2MAPT | |
| SCHEMBL29648404 | 0.86 | CYP19A1 (0.45) | CYP19A1ALDH1A1PTGS2CA1CA2 | |
| SCHEMBL24496309 | 0.86 | CYP19A1 (0.45) | CYP19A1ALDH1A1PTGS2CA1CA2 | |
| SCHEMBL29648340 | 0.86 | PTGS2 (0.43) | CYP19A1ALOX15PTGS2CA1CA2 | |
| SCHEMBL24496010 | 0.86 | ALDH1A1 (0.51) | CYP19A1ALDH1A1CA1CA2MAPT | |
| SCHEMBL24496152 | 0.84 | CNR2 (0.47) | CYP19A1CA1CA2MEN1KMT2A | |
| SCHEMBL24496051 | 0.84 | MMP1 (0.49) | CYP19A1ALDH1A1CA1CA2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |