Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.49 |
| ▸ | YAP1 | P46937 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648382 | 1.00 | TEAD1 (0.49) | TEAD1YAP1MAPTTRPV1CDK2 | |
| SCHEMBL24496331 | 0.91 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1CYP19A1 | |
| SCHEMBL22718121 | 0.88 | ALOX15 (0.43) | TEAD1YAP1MAPTLMNA | |
| SCHEMBL22718064 | 0.87 | TEAD1 (0.65) | TEAD1YAP1MAPTTRPV1CDK2 | |
| SCHEMBL24496290 | 0.86 | TEAD1 (0.50) | TEAD1YAP1MAPTTRPV1TLR2 | |
| SCHEMBL20766734 | 0.85 | TEAD1 (0.60) | TEAD1YAP1MAPTCDK2CDK7 | |
| SCHEMBL29901824 | 0.85 | TEAD1 (0.60) | TEAD1YAP1MAPTCDK2CDK7 | |
| SCHEMBL20779719 | 0.81 | TEAD1 (0.74) | TEAD1YAP1MAPTMAPK1TLR2 | |
| SCHEMBL22718177 | 0.80 | TEAD1 (0.55) | TEAD1YAP1MAPTTLR2TLR1 | |
| SCHEMBL25790239 | 0.79 | TEAD1 (0.54) | TEAD1YAP1MAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |