Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.50 |
| ▸ | YAP1 | P46937 | 1/20 | 0.50 |
| ▸ | TLR2 | O60603 | 3/20 | 0.38 |
| ▸ | TLR1 | Q15399 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496331 | 0.88 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL29438830 | 0.87 | TEAD1 (0.66) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL22718065 | 0.87 | TEAD1 (0.66) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL24496086 | 0.86 | TEAD1 (0.49) | TEAD1YAP1TLR2TLR1TRPV1 | |
| SCHEMBL29648382 | 0.86 | TEAD1 (0.49) | TEAD1YAP1TLR2TLR1TRPV1 | |
| SCHEMBL20779719 | 0.82 | TEAD1 (0.74) | TEAD1YAP1TLR2TLR1MAPT | |
| SCHEMBL22718121 | 0.80 | ALOX15 (0.43) | TEAD1YAP1KDM4EBRD4MAPT | |
| SCHEMBL22718177 | 0.79 | TEAD1 (0.55) | TEAD1YAP1TLR2TLR1MAPT | |
| SCHEMBL20766734 | 0.79 | TEAD1 (0.60) | TEAD1YAP1TLR2TLR1KDM4E | |
| SCHEMBL22718131 | 0.79 | TEAD1 (0.58) | TEAD1YAP1TLR2TLR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |