Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.59 |
| ▸ | YAP1 | P46937 | 1/20 | 0.59 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 5/20 | 0.43 |
| ▸ | TLR2 | O60603 | 4/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496353 | 0.88 | TEAD1 (0.57) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29438880 | 0.87 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718190 | 0.87 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718126 | 0.86 | TEAD1 (0.55) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718107 | 0.84 | TEAD1 (0.53) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29438867 | 0.84 | TEAD1 (0.53) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718252 | 0.83 | TEAD1 (0.59) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29704149 | 0.82 | TNNI3K (0.47) | TEAD1YAP1TNNI3KMAPTTLR2 | |
| SCHEMBL22718131 | 0.81 | TEAD1 (0.58) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24496050 | 0.81 | TEAD1 (0.39) | TEAD1YAP1MAPTTLR2TLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |