Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.53 |
| ▸ | YAP1 | P46937 | 1/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718107 | 1.00 | TEAD1 (0.53) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718126 | 0.89 | TEAD1 (0.55) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22843429 | 0.87 | TEAD1 (0.39) | TEAD1YAP1TNNI3KMAPTKDM5B | |
| SCHEMBL24496280 | 0.84 | TEAD1 (0.59) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24496353 | 0.84 | TEAD1 (0.57) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718290 | 0.83 | CCR6 (0.37) | TEAD1YAP1MAPTKMT2ANPSR1 | |
| SCHEMBL29438945 | 0.83 | CCR6 (0.37) | TEAD1YAP1MAPTKMT2ANPSR1 | |
| SCHEMBL22718190 | 0.82 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29438880 | 0.82 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718252 | 0.80 | TEAD1 (0.59) | TEAD1YAP1TNNI3KMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |