SCHEMBL2449714

SCHEMBL2449714

Cc1cc2nc3cc(O)c(O)cc3nc2cc1C

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.68
MAPT P10636 3/20 0.68
NQO2 P16083 3/20 0.56
NPC1 O15118 4/20 0.46
RAB9A P51151 3/20 0.46
ALDH1A1 P00352 4/20 0.43
G6PD P11413 2/20 0.39
PKM P14618 2/20 0.39
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
GAA P10253 2/20 0.39
AMY1A P0DUB6 1/20 0.38
RPS6KB2 Q9UBS0 1/20 0.38
PDGFRB P09619 2/20 0.37
PDGFRA P16234 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
CYP3A4 P08684 2/20 0.37
HPGD P15428 2/20 0.37
TP53 P04637 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15581107 0.92 KDM4E (0.58) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL13388975 0.85 NQO2 (0.72) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL9979780 0.85 MAPT (0.46) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL27437406 0.82 KDM4E (0.48) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL26418768 0.82 KDM4E (0.48) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL15581106 0.80 KDM4E (0.46) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL1259502 0.80 KDM4E (0.64) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL10784379 0.79 KDM4E (0.50) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL6206349 0.79 NQO2 (0.71) KDM4EMAPTNQO2NPC1RAB9A
SCHEMBL21729804 0.77 KDM4E (0.44) KDM4EMAPTNQO2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011117830-A1 DERIVATIVES OF PHENAZINE USEFUL TO TREAT CANCER Université de la Méditerranée AIX-Marseille II (FR) 2011-09-29 WO claimed
WO-2011117830-A1 DERIVATIVES OF PHENAZINE USEFUL TO TREAT CANCER Université de la Méditerranée AIX-Marseille II (FR) 2011-09-29 WO disclosed
EP-2078720-A1 Novel method for the preparation of derivatives of dihydrotetraazapentacenes, products such as obtained and uses thereof Université de la Méditerranée - Aix-Marseille II (FR) 2009-07-15 EP disclosed
EP-2078720-A1 Novel method for the preparation of derivatives of dihydrotetraazapentacenes, products such as obtained and uses thereof Université de la Méditerranée - Aix-Marseille II (FR) 2009-07-15 EP disclosed
WO-2009083532-A2 NOVEL METHOD FOR THE PREPARATION OF DERIVATIVES OF DIHYDROTETRAAZAPENTACENES, PRODUCTS SUCH AS OBTAINED, AND USES THEREOF UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II (FR) 2009-07-09 WO disclosed
WO-2009083532-A2 NOVEL METHOD FOR THE PREPARATION OF DERIVATIVES OF DIHYDROTETRAAZAPENTACENES, PRODUCTS SUCH AS OBTAINED, AND USES THEREOF UNIVERSITE DE LA MEDITERRANEE AIX-MARSEILLE II (FR) 2009-07-09 WO disclosed