SCHEMBL2576322

SCHEMBL2576322

Nc1ccc(Oc2cccc(C(F)(F)F)c2)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.52
L3MBTL1 Q9Y468 3/20 0.52
NPSR1 Q6W5P4 1/20 0.52
TSHR P16473 1/20 0.51
MAPK1 P28482 1/20 0.51
MAOB P27338 2/20 0.44
ADORA2A P29274 1/20 0.43
RAB9A P51151 1/20 0.42
POLB P06746 2/20 0.41
EGFR P00533 1/20 0.41
ERBB2 P04626 1/20 0.41
HSP90AA1 P07900 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
TEAD1 P28347 1/20 0.41
ICAM1 P05362 1/20 0.41
SELE P16581 1/20 0.41
EPAS1 Q99814 1/20 0.41
LMNA P02545 1/20 0.40
PKM P14618 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29638122 0.84 EGFR (0.53) MAPTL3MBTL1NPSR1TSHRMAPK1
SCHEMBL2748096 0.84 L3MBTL1 (0.55) MAPTL3MBTL1NPSR1TSHRMAPK1
SCHEMBL2747848 0.84 EGFR (0.53) MAPTL3MBTL1NPSR1TSHRMAPK1
SCHEMBL2748407 0.82 L3MBTL1 (0.60) MAPTL3MBTL1NPSR1TSHRMAPK1
SCHEMBL883804 0.81 TSHR (0.50) MAPTL3MBTL1NPSR1TSHRMAPK1
SCHEMBL875921 0.81 MAOB (0.50) MAPTL3MBTL1NPSR1MAOBPOLB
SCHEMBL24497305 0.81 TEAD1 (0.53) MAPTL3MBTL1NPSR1TSHRMAPK1
SCHEMBL22809770 0.81 MAPT (0.62) MAPTL3MBTL1NPSR1MAPK1RAB9A
SCHEMBL24999539 0.81 L3MBTL1 (0.51) MAPTL3MBTL1NPSR1RAB9ATEAD1
SCHEMBL6153537 0.80 TSHR (0.68) MAPTL3MBTL1NPSR1TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2385037-A1 Fungicidal phenoxyphenylhydrazine derivatives Chemtura Corporation (US) 2011-11-09 EP disclosed
US-7045512-B2 Fungicidal phenoxyphenylhydrazine derivatives UNIROYAL CHEMICAL COMPANY, INC. (US) 2006-05-16 US disclosed
US-20040266738-A1 Fungicidal phenoxyphenylhydrazine derivatives CROMPTON COLORS INCORPORATED 2004-12-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040266738-A1 Fungicidal phenoxyphenylhydrazine derivatives CBR1, CBR3, CNPY2 MAPT 4825/4885L3MBTL1 231/4885NPSR1 2179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.