Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648442 | 1.00 | TNNI3K (0.55) | TNNI3KMAPTBRAFTEAD1YAP1 | |
| SCHEMBL29648339 | 0.85 | MAPT (0.53) | TNNI3KMAPTBRAFTEAD1YAP1 | |
| SCHEMBL24497432 | 0.85 | MAPT (0.53) | TNNI3KMAPTBRAFTEAD1YAP1 | |
| SCHEMBL22719765 | 0.83 | TEAD1 (0.56) | TNNI3KMAPTTEAD1YAP1MEN1 | |
| SCHEMBL29504945 | 0.83 | TEAD1 (0.56) | TNNI3KMAPTTEAD1YAP1MEN1 | |
| SCHEMBL22719577 | 0.78 | MAPT (0.57) | TNNI3KMAPTBRAFTEAD1YAP1 | |
| SCHEMBL24497429 | 0.78 | MAPT (0.66) | TNNI3KMAPTTEAD1YAP1MAPK10 | |
| SCHEMBL22718227 | 0.77 | TNNI3K (0.54) | TNNI3KMAPTBRAFTEAD1YAP1 | |
| SCHEMBL29438827 | 0.77 | TNNI3K (0.54) | TNNI3KMAPTBRAFTEAD1YAP1 | |
| SCHEMBL24497405 | 0.77 | MAPT (0.44) | MAPTKDM4EMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |