Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.56 |
| ▸ | YAP1 | P46937 | 1/20 | 0.56 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719765 | 1.00 | TEAD1 (0.56) | TEAD1YAP1TNNI3KALDH3A1MAPK1 | |
| SCHEMBL22719577 | 0.87 | MAPT (0.57) | TEAD1YAP1TNNI3KMEN1KMT2A | |
| SCHEMBL29648442 | 0.83 | TNNI3K (0.55) | TEAD1YAP1TNNI3KMEN1KMT2A | |
| SCHEMBL24497379 | 0.83 | TNNI3K (0.55) | TEAD1YAP1TNNI3KMEN1KMT2A | |
| SCHEMBL20779892 | 0.82 | TEAD1 (0.62) | TEAD1YAP1TNNI3KALDH3A1MAPK1 | |
| SCHEMBL24497321 | 0.80 | TNNI3K (0.50) | TEAD1YAP1TNNI3KMAPK1MEN1 | |
| SCHEMBL22635666 | 0.78 | ALDH1A1 (0.58) | TEAD1YAP1TNNI3KMAPK1MEN1 | |
| SCHEMBL20779642 | 0.78 | TEAD1 (0.56) | TEAD1YAP1TNNI3KALDH3A1MAPK1 | |
| SCHEMBL30410558 | 0.78 | TEAD1 (0.56) | TEAD1YAP1TNNI3KALDH3A1MAPK1 | |
| SCHEMBL20766837 | 0.76 | TEAD1 (0.54) | TEAD1YAP1TNNI3KALDH3A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976192-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |