Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.54 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.53 |
| ▸ | YAP1 | P46937 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CCR6 | P51684 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 4/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718227 | 1.00 | TNNI3K (0.54) | TNNI3KTEAD1YAP1MAPTCCR6 | |
| SCHEMBL24496003 | 0.85 | TEAD1 (0.50) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL24496013 | 0.84 | TEAD1 (0.49) | TNNI3KTEAD1YAP1MAPTCCR6 | |
| SCHEMBL29648401 | 0.83 | TEAD1 (0.51) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL24496260 | 0.83 | TEAD1 (0.51) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL29438880 | 0.83 | TEAD1 (0.77) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL22718190 | 0.83 | TEAD1 (0.77) | TNNI3KTEAD1YAP1MAPTBRAF | |
| SCHEMBL22843482 | 0.83 | CCR6 (0.43) | TNNI3KTEAD1YAP1MAPTCCR6 | |
| SCHEMBL24496005 | 0.83 | TNNI3K (0.51) | TNNI3KTEAD1YAP1MAPTCCR6 | |
| SCHEMBL29648405 | 0.83 | TNNI3K (0.51) | TNNI3KTEAD1YAP1MAPTCCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |