Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 16/20 | 0.74 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497320 | 1.00 | TEAD1 (0.74) | TEAD1TNNI3KYAP1MAPTBRAF | |
| SCHEMBL29648430 | 1.00 | TEAD1 (0.74) | TEAD1TNNI3KYAP1MAPTBRAF | |
| SCHEMBL29110484 | 1.00 | TEAD1 (0.74) | TEAD1TNNI3KYAP1MAPTBRAF | |
| SCHEMBL24497430 | 0.89 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL29648411 | 0.89 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL29648418 | 0.89 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL24497323 | 0.89 | TEAD1 (0.58) | TEAD1TNNI3KYAP1MAPTBRAF | |
| SCHEMBL29110458 | 0.89 | TEAD1 (0.58) | TEAD1TNNI3KYAP1MAPTBRAF | |
| SCHEMBL29648369 | 0.89 | TEAD1 (0.58) | TEAD1TNNI3KYAP1MAPTBRAF | |
| SCHEMBL22719850 | 0.85 | TEAD1 (1.00) | TEAD1TNNI3KYAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561061-A | Combination of 3- (imidazol-4-yl) -4- (amino) -benzenesulfonamide TEAD inhibitors with EGFR inhibitors and/or MEK inhibitors for the treatment of lung cancer | 医肯纳肿瘤学公司 | 2024-02-13 | — | — | CN | disclosed |
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| CN-117015531-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2023-11-07 | — | — | CN | disclosed |
| EP-4255895-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |