Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.58 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497323 | 1.00 | TEAD1 (0.58) | TEAD1TNNI3KMAPTYAP1MEN1 | |
| SCHEMBL29648369 | 1.00 | TEAD1 (0.58) | TEAD1TNNI3KMAPTYAP1MEN1 | |
| SCHEMBL29110484 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTYAP1BRAF | |
| SCHEMBL24497408 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTYAP1BRAF | |
| SCHEMBL29648430 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTYAP1BRAF | |
| SCHEMBL24497320 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTYAP1BRAF | |
| SCHEMBL24497430 | 0.78 | TEAD1 (0.61) | TEAD1TNNI3KMAPTMEN1KMT2A | |
| SCHEMBL24497415 | 0.78 | TEAD1 (0.61) | TEAD1TNNI3KMAPTYAP1BRAF | |
| SCHEMBL24497414 | 0.78 | TEAD1 (0.61) | TEAD1TNNI3KMAPTYAP1BRAF | |
| SCHEMBL29648418 | 0.78 | TEAD1 (0.61) | TEAD1TNNI3KMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561061-A | Combination of 3- (imidazol-4-yl) -4- (amino) -benzenesulfonamide TEAD inhibitors with EGFR inhibitors and/or MEK inhibitors for the treatment of lung cancer | 医肯纳肿瘤学公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117015531-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2023-11-07 | — | — | CN | disclosed |