SCHEMBL24498142

SCHEMBL24498142

Cc1ccc(Br)cc1N(C)S(C)(=O)=O

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.40
CYP19A1 P11511 3/20 0.39
KMT2A Q03164 3/20 0.38
MEN1 O00255 1/20 0.38
CYP2C9 P11712 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
C5AR1 P21730 1/20 0.35
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.34
EDNRB P24530 2/20 0.33
EDNRA P25101 2/20 0.33
HTT P42858 1/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA12 O43570 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20500621 0.85 CYP19A1 (0.42) POLBCYP19A1KMT2AMEN1C5AR1
SCHEMBL30526754 0.85 CYP19A1 (0.42) POLBCYP19A1KMT2AMEN1C5AR1
SCHEMBL21375770 0.81 LMNA (0.48) POLBCYP19A1KMT2AMEN1CYP2C9
SCHEMBL11285033 0.80 ALDH1A1 (0.45) CYP19A1KMT2AMEN1NPSR1LMNA
SCHEMBL20092981 0.80 CYP19A1 (0.41) POLBCYP19A1KMT2AC5AR1CA1
SCHEMBL26544597 0.80 CYP19A1 (0.39) POLBCYP19A1KMT2ANPSR1C5AR1
SCHEMBL2760306 0.78 PSEN1 (0.44) POLBCYP19A1KMT2AMEN1CYP2C9
SCHEMBL24497945 0.78 TSHR (0.47) POLBCYP19A1KMT2AMEN1NPSR1
SCHEMBL24497547 0.77 CYP19A1 (0.37) POLBCYP19A1KMT2ALMNATSHR
SCHEMBL3986851 0.76 SIRT2 (0.45) CYP19A1KMT2ALMNACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4257587-A1 HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shenzhen Chipscreen Biosciences Co., Ltd. (CN) 2023-10-11 EP disclosed
WO-2022117016-A1 HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 深圳微芯生物科技股份有限公司 2022-06-09 WO disclosed