Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24499502 | 0.81 | MEN1 (0.63) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| SCHEMBL24499469 | 0.78 | PDK1 (0.57) | MEN1KMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL24499507 | 0.75 | POLB (0.58) | TP53POLBL3MBTL1 | |
| SCHEMBL16144910 | 0.75 | MEN1 (0.67) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| SCHEMBL13767851 | 0.73 | MEN1 (0.64) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| SCHEMBL4894293 | 0.73 | MEN1 (0.72) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| Benoxacor SCHEMBL122820 | 0.71 | ALDH1A1 (0.67) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| Benoxacor SCHEMBL3674598 | 0.71 | ALDH1A1 (0.67) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| Benoxacor SCHEMBL29419104 | 0.71 | ALDH1A1 (0.67) | MAPTMEN1KMT2AHSD11B1CRHBP | |
| Benoxacor SCHEMBL29963816 | 0.71 | ALDH1A1 (0.67) | MAPTMEN1KMT2AHSD11B1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022117920-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | ORION CORPORATION (FI) | 2022-06-09 | — | — | WO | disclosed |