Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29597821 | 1.00 | ALDH1A1 (0.53) | ALDH1A1MAPTMAPK1LMNASMN1; SMN2 | |
| SCHEMBL29598005 | 0.82 | POLB (0.64) | ALDH1A1SMN1; SMN2RAB9APDE4BPDE4D | |
| SCHEMBL27197599 | 0.82 | POLB (0.64) | ALDH1A1SMN1; SMN2RAB9APDE4BPDE4D | |
| SCHEMBL29597607 | 0.81 | MAPT (0.66) | ALDH1A1MAPTLMNASMN1; SMN2ROCK2 | |
| SCHEMBL24499954 | 0.81 | MAPT (0.66) | ALDH1A1MAPTLMNASMN1; SMN2ROCK2 | |
| SCHEMBL29597263 | 0.80 | DRD2 (0.52) | RAB9ACYP11B2L3MBTL1 | |
| SCHEMBL24499909 | 0.80 | DRD2 (0.52) | RAB9ACYP11B2L3MBTL1 | |
| SCHEMBL24499915 | 0.79 | DRD2 (0.57) | ALDH1A1SMN1; SMN2RAB9ACYP11B2MEN1 | |
| SCHEMBL29597170 | 0.79 | DRD2 (0.57) | ALDH1A1SMN1; SMN2RAB9ACYP11B2MEN1 | |
| SCHEMBL24499945 | 0.75 | STAT3 (0.62) | ALDH1A1SMN1; SMN2RAB9ACYP11B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116724034-A | 2, 3-dihydro-4H-benzo [ B ] [1,4] oxazin-4-yl (5- (phenyl) -pyridin-3-yl) methanone derivatives and similar compounds as CYP11A1 inhibitors for the treatment of prostate cancer | 奥赖恩公司 | 2023-09-08 | — | — | CN | claimed |
| CN-116724034-A | 2, 3-dihydro-4H-benzo [ B ] [1,4] oxazin-4-yl (5- (phenyl) -pyridin-3-yl) methanone derivatives and similar compounds as CYP11A1 inhibitors for the treatment of prostate cancer | 奥赖恩公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2022117920-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | ORION CORPORATION (FI) | 2022-06-09 | — | — | WO | disclosed |