Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 5/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16767389 | 0.75 | PLA2G10 (0.60) | PLA2G10RAB9ANPC1SMN1; SMN2DYRK1A | |
| SCHEMBL1328163 | 0.74 | PLA2G10 (1.00) | PLA2G10RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL15999120 | 0.72 | PLA2G10 (0.56) | PLA2G10RAB9ANPC1DYRK1AFABP4 | |
| SCHEMBL5151890 | 0.72 | DHODH (0.69) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2467813 | 0.71 | DYRK1A (0.54) | PLA2G10RAB9ANPC1SMN1; SMN2DYRK1A | |
| SCHEMBL5094845 | 0.70 | KDM4E (0.52) | PLA2G10RAB9ANPC1SMN1; SMN2DYRK1A | |
| SCHEMBL31118894 | 0.70 | CHEK1 (0.51) | MAPTALDH1A1 | |
| SCHEMBL27197596 | 0.69 | SCD5 (0.52) | CYP11B2ALDH1A1 | |
| SCHEMBL6246566 | 0.69 | PLA2G10 (0.59) | PLA2G10RAB9ANPC1SMN1; SMN2DYRK1A | |
| SCHEMBL319106 | 0.69 | CHEK1 (0.50) | SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116724034-A | 2, 3-dihydro-4H-benzo [ B ] [1,4] oxazin-4-yl (5- (phenyl) -pyridin-3-yl) methanone derivatives and similar compounds as CYP11A1 inhibitors for the treatment of prostate cancer | 奥赖恩公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2022117920-A1 | 2,3-DIHYDRO-4H-BENZO[B][1,4]OXAZIN-4-YL)(5-(PHENYL)-PYRIDIN-3-YL)METHANONE DERIVATIVES AND SIMILAR COMPOUNDS AS CYP11A1 INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | ORION CORPORATION (FI) | 2022-06-09 | — | — | WO | disclosed |