Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22425870 | 0.89 | CSNK1D (0.38) | ALDH1A1CSNK1DMAPK1POLBKDM4E | |
| SCHEMBL22425935 | 0.87 | ALDH1A1 (0.35) | ALDH1A1CSNK1DMAPK1LMNASMN1; SMN2 | |
| SCHEMBL22425827 | 0.87 | ALDH1A1 (0.35) | ALDH1A1CSNK1DMAPK1LMNASMN1; SMN2 | |
| SCHEMBL24500833 | 0.84 | ALDH1A1 (0.35) | ALDH1A1CSNK1DMAPK1LMNASMN1; SMN2 | |
| SCHEMBL20697290 | 0.81 | ALDH1A1 (0.41) | ALDH1A1CSNK1DMAPK1LMNAPOLB | |
| SCHEMBL24500702 | 0.80 | P2RX3 (0.33) | ALDH1A1 | |
| SCHEMBL22426017 | 0.79 | P2RX3 (0.35) | CSNK1DLMNADRD2DRD4DRD3 | |
| SCHEMBL24500567 | 0.79 | KDM4E (0.32) | ALDH1A1MAPK1LMNASMN1; SMN2KDM4E | |
| SCHEMBL21246014 | 0.79 | TP53 (0.46) | ALDH1A1CSNK1DLMNAPOLBKDM4E | |
| SCHEMBL24500709 | 0.79 | PDE2A (0.35) | ALDH1A1CSNK1DMAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177486-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177486-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | ALDH1A1 4098/4885CSNK1D 822/4885MAPK1 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.