Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497427 | 0.85 | TEAD1 (0.50) | TEAD1YAP1TRPV1KCNH2GABRA1 | |
| SCHEMBL29648357 | 0.85 | TEAD1 (0.50) | TEAD1YAP1TRPV1KCNH2GABRA1 | |
| SCHEMBL24501692 | 0.83 | TEAD1 (0.59) | TEAD1YAP1KCNH2GABRA1GABRG2 | |
| SCHEMBL24790230 | 0.82 | TEAD1 (0.50) | TEAD1YAP1TRPV1KCNH2GABRA1 | |
| SCHEMBL24496101 | 0.81 | TEAD1 (0.49) | TEAD1YAP1TRPV1KCNH2JAK1 | |
| SCHEMBL24501068 | 0.81 | TEAD1 (0.61) | TEAD1YAP1KCNH2GABRA1GABRG2 | |
| SCHEMBL24501728 | 0.81 | TEAD1 (0.61) | TEAD1YAP1TRPV1KCNH2GABRA1 | |
| SCHEMBL24496100 | 0.80 | TLR2 (0.51) | TEAD1YAP1TRPV1KCNH2JAK1 | |
| SCHEMBL22718190 | 0.80 | TEAD1 (0.77) | TEAD1YAP1TSHRL3MBTL1MAPK10 | |
| SCHEMBL29438880 | 0.80 | TEAD1 (0.77) | TEAD1YAP1TSHRL3MBTL1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |