Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19449335 | 0.96 | POLB (0.44) | POLBGAASMN1; SMN2CDK2CCNA2 | |
| SCHEMBL22717781 | 0.94 | POLB (0.40) | POLBGAASMN1; SMN2CDK2CCNA2 | |
| SCHEMBL24501285 | 0.86 | POLB (0.35) | POLBGAASMN1; SMN2GLSALDH1A1 | |
| SCHEMBL24501049 | 0.85 | DHFR (0.39) | POLBGAASMN1; SMN2MCHR1GLS | |
| SCHEMBL24500857 | 0.83 | POLB (0.35) | POLBGAASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL29108540 | 0.82 | FEN1 (0.35) | POLBGAAGLS | |
| SCHEMBL24501232 | 0.82 | KDM5A (0.33) | POLBGAA | |
| SCHEMBL24501428 | 0.81 | POLB (0.33) | POLBGAAMCHR1 | |
| SCHEMBL24501417 | 0.80 | BACE1 (0.34) | POLBGAA | |
| SCHEMBL24501584 | 0.80 | LRRK2 (0.32) | POLBGAAGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023233295-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | IDEAYA BIOSCIENCES, INC. (US) | 2023-12-07 | — | — | WO | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |